IIT Madras creates “MultiCens” to research the human body’s inter-organ communication network

A computer method called “MultiCens” has been created by researchers at the Indian Institute of Technology Madras (IIT Madras) to better understand the communication between organs and tissues in the human body.

The Robert Bosch Centre for Data Science and Artificial Intelligence (RBC-DSAI) was the site of the study. The inter-organ communication networks (ICNs) in the human body and their function in preserving general health and well-being will now be clear to understand.

The most recent studies at IIT Madras will concentrate on thorough genome-wide searches for genes and chemicals regulating tissue-tissue signalling.

According to this, multicellular organisms must have interactions between cells in various tissues and organs in order to operate properly and survive.
Information sharing enables organisms to assess their energy supplies, adjust to environmental changes, and control a number of physiological processes.

A computer method called “MultiCens” (Multilayer/Multi-tissue network Centrality measurements) will use genomic data from multiple tissues to detect and analyse the relationships between genes in charge of communication between various organs.

ICN studies have traditionally depended significantly on trials carried out on model species like fruit flies. The IIT Madras scientists have studied ICNs more thoroughly and effectively since the launch of MultiCens. The identification of important genes involved in interorgan communication under varied healthy or illness situations is made possible by this strategy.

MultiCens can reveal changes in gene connections within various brain regions impacted by illnesses like Alzheimer’s disease and will aid in predicting genes linked to hormones, which are essential for many body activities. Additionally, it will aid in the comprehension of cancer metastasis, in which cancer cells gradually travel from one organ to another.

Published in the PLOS Computational Biology publication are the study’s findings. In addition to Ramanathan Sethuraman, an Intel Corporation researcher who worked with the IIT Madras team, the paper was co-authored by Tarun Kumar, Sanga Mitra, B Ravindran, and Manikandan Narayanan.

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